PRODUCTION OF AMINODISACCHARIDE AND CHITIN OR ITS ANALOGUE POLYSACCHARIDES

摘要

PURPOSE: To obtain a new aminodisaccharide comprising specific aminodisaccharides having oxazoline ring structure, capable of providing chitin or analogue polysaccharides by polyaddition reaction due to the action of chitinase and useful e.g. as a raw material for chitin or chitosan. CONSTITUTION: This new aminodisaccharide comprises 2-methyl- 4-O-[2- acetamide-2-deoxy-β-glucopyranosyl]-l,2-dideoxy-α-glucopyrano} [2,1-d]-2- oxazoline expressed by formula I. The compound is reacted with chitinase in a buffer and subjected to polyaddition reaction due to enzyme catalyst to provide a chitin or its analogue polysaccharides. The aminodisaccharide is useful as a producing raw material for chitin or chitosan which has no problem on security of a raw material. The aminodisaccharide is obtained by reacting di-N-acetylchito-biosehexacetate with acetyl chloride in the presence of a base to chlorinate the acetate derivative and reacting the resultant chlorinated compound with acetonitrile in the presence of tetraethylammonium chloride, and further deprotecting hydroxyl group.