| 摘要 |
PROBLEM TO BE SOLVED: To obtain a promoter for the synthesis of a ceramide, capable of activating the synthesis of the ceramide by a cell itself in the epidermal layer of the skin, improving the skin barrier functions and effective in reducing roughened skin and various dermatopathies. SOLUTION: This promoter for the synthesis of a ceramide contains nicotinic acid or its derivative of the formula [R1 is H; R2 is free or R1 is OH and R2 is free or aliphatic monoamines or R1 is NH2 and R3 is free or a monovalent organic acid salt or R1 is OR3 (R3 is an alkali metal, a 1-10C alkyl, etc.) and R2 is free] or a nicotinic alcohol or its salt as an active ingredient in an amount of 0.00001-5wt.% based on the total composition in a dermal preparation for external use. When the promoter for the synthesis of the ceramide is used for producing the ceramide and sphingolipid raw material, etc., widely used for various cosmetics and medicinal materials, the promoter is added in an amount of 10μm to 1mM final concentration to a culture medium for epidermal cells. The promoter is useful for dermatopathies such as atopic dermatitis, psoriasis, etc.
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