Oxaindene derivatives and a process for preparing them as well as medicaments containing them and the use of them

摘要

A subject-matter of the invention are oxaindene derivatives of general formula <CHEM> wherein R1 represents a C1-4-alkyl, C1-4-alkoxy or C3-6-cycloalkyl group, R2 stands for hydrogen or a C1-4-alkyl or C3-6-cycloalkyl group, R3 represents hydrogen or a C1-4-alkyl, C1-4-alkoxy or benzyloxy group, X means hydrogen, an aliphatic C1-4-acyl or benzoyl or naphthoyl group, optionally substituted by 1 or more nitro or C1-4-alkoxy group(s) or a group of formula <CHEM> in which latter R7 stands for a C1-4-alkylene group and R5 and R6 each represents a C1-4-alkyl group or R5 and R6 together with the nitrogen atom to which they are attached form a piperidyl or morpholinyl group, A and B together form an ethylene or a vinylene group and n is 1, 2 or 3, and their stereoisomers and their mixtures as well as acid addition salts of these compounds. Moreover there are provided for a process for preparing these compounds, medicaments containing them and the use of these compounds. They have a strong 5-lipoxygenase enzyme inhibiting activity.