| 摘要 |
Use of ester and amide derivs. of 9(Z)-retinoic acid having formula (I) for the treatment of cancer is claimed. Y = -OC(R1)2COR2 (a); a gp. e.g. (b)-(i); R1 = H, 1-20C alkyl or 1-20C alkanoyl; R2 = 1-4C alkyl, -CH2OH, -N(R3)2, -CH2-O-CO-R3, or a phenyl, pyridyl, furanyl, thiophenyl of pyrrolyl ring which may be n-substd. (n = 0-5) by X; R3 = H or 1-4C alkyl; X = H, F, Cl, Br, I, OH, OR3, NH2, NO2, CN, NHR3, N(R3)2, SH, SR3, -O-CO-R3, -CO-R3, CHO or COOR3. Cpds. (I) are new where Y = e.g. (b)-(i) or a gp. (t) in which C' = COOMe or CH2COMe. |
