发明名称 |
Cloning of the biosynthetic pathway for chlortetracycline and tetracycline formation and cosmids useful therein |
摘要 |
The present invention describes a purified and isolated nucleic acid molecule which encodes for the biosynthetic pathway of tetracycline, chlortetracycline or an analogue thereof. The invention relates to the isolation and cloning of the nucleic acid molecule in an isolated fragment from Streptomyces aureofaciens and the expression of the biosynthetic gene in a heterologous host such as Streptomyces lividans.
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申请公布号 |
US5589385(A) |
申请公布日期 |
1996.12.31 |
申请号 |
US19930125468 |
申请日期 |
1993.09.22 |
申请人 |
AMERICAN CYANAMID COMPANY |
发明人 |
RYAN, MICHAEL J.;LOTVIN, JASON A.;STRATHY, NANCY;FANTINI, SUSAN E. |
分类号 |
C12N15/52;C12N15/76;C12P29/00;C12Q1/18;(IPC1-7):C12N1/21 |
主分类号 |
C12N15/52 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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