发明名称 |
Recombinant adeno-associated virus vectors |
摘要 |
Simplified methods to produce recombinant adeno-associated virus (rAAV) vectors are described. The AAV rep and cap genes are combined in a single recombinant adenovirus vector, i.e., a rep/cap adenovirus vector which combines in a single vector all complementing functions required for rAAV production. The rep/cap vectors of the present invention comprise: genes encoding helper functions, preferably from adenovirus, sufficient to permit AAV replication; and AAV cap and rep genes. In adenovirus rep/cap vectors the rep and cap genes may, for example, replace the adenovirus E3 gene or the adenovirus E1a and E1b genes.
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申请公布号 |
US5589377(A) |
申请公布日期 |
1996.12.31 |
申请号 |
US19950490095 |
申请日期 |
1995.06.06 |
申请人 |
RH+E,CIR O+EE NE-POULENC RORER PHARMACEUTICALS, INC. |
发明人 |
LEBKOWSKI, JANE S.;MCNALLY, MAUREEN A.;OKARMA, THOMAS B. |
分类号 |
C12N5/10;C07K14/015;C07K14/05;C12N7/00;C12N7/04;C12N15/09;C12N15/38;C12N15/864;C12N15/869;C12R1/92;(IPC1-7):C12N5/10;C12N7/01;C12N15/86 |
主分类号 |
C12N5/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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