Pyrazole-related derivatives endowed with antitumor and anti viral activities, procedures for their preparation, pharmace utical formulations containing them

摘要

Pyrazole-related derivatives having general formula (I) are described, wherein R is COOH, COOR', and (III) and R' is a C1-C5 alkyl radical, R<1> is I, Br, Cl, F, CF3, CN, SCN, CHO, CH=CH2, CH=CH Br, CC-Si(CH3)3, CH=CH COOCH2CH3, CCH, CH2=CH NO2, n is 0 or 1, R<2> is H, CH2OH, CH2 OCOPh, CH2O Si(CH3)2C(CH3)3, CH2OPO3 Na2, CH2OPO[OCH2O-COC(CH3)3]2, CH2OPO[O CH2 CH2 SCOC(CH3)3]2, R<3> and R<4> equal or different from each other are H, OH, CH2 OCOPh, CH2O Si(CH3)2C(CH3)3, or they form together an isopropylidene group, provided that when R<2> = R<3> = R<4> = H n is always 1, and with the exclusion of the compound having R=COOCH3, R<1> = I, n=O, R<3> = CH2 OCOPh, R<3> = R<4>=OCOPh. These compounds are endowed with antitumor and are able to enhance antiviral activity of known antiviral agents. The procedures for preparation of compounds of formula (I) and of pharmaceutical formulations containing them are also reported.