摘要 |
The present invention provides new methods of inhibiting the proliferation of cells or inhibiting the production of cytokines in blood products by treating blood products with a psoralen compound, then photoactivating the compound by exposing the blood product to ultraviolet light. The present invention specifically provides methods of using new and known compounds to inactivate leukocytes in blood products to be used in vivo and in vitro without significantly effecting blood product function or exhibiting mutagenicity. The methods of the present invention also result in the inactivation of any pathogens in the blood products treated. |