Ether derivatives of pseudopterosin

摘要

Methods for treating mammals to reduce pain and/or reduce inflammation are described based on administering to the mammals synthetic ether derivatives of pseudopterosin having the formula: wherein A is an alkyl, aryl or amide group having from 2 to 20 carbon atoms, R1, R2 and R3 are hydrogen or an acyl residue (-COR) having from 1 to 6 carbon atoms, R4 is hydrogen or -CH2OH and R5 is a hydrocarbon having from 1 to 10 carbon atoms. Also disclosed are synthetic compositions having the above general formula which are useful in the described method.