发明名称 |
Process and primers for identifying nucleic acids encoding A-lineage conotoxin peptides |
摘要 |
The invention is directed to A-lineage conotoxin peptides, which are conotoxin peptides that have strong homology in the signal sequence and the 3'-untranslated region of the genes coding for these peptides to the sequences in the alpha -conotoxin peptides. The A-lineage conotoxin peptides include the alpha -conotoxin peptides, the alpha -conotoxin-like peptides and the kappa -conotoxin peptides, described further below. The alpha -conotoxin-peptides generally share a "core" sequence motif. This core sequence is termed the alpha +E,fra 3/5+EE core and is represented as Cys-Cys-Xaa-Xaa-Xaa-Cys-Xaa-Xaa-Xaa-Xaa-Xaa-Cys (SEQ ID NO: 1). The alpha -conotoxin-like peptides generally share a core sequence termed the alpha +E,fra 4/7+EE core and is represented as Cys-Cys-Xaa-Xaa-Xaa-Xaa-Cys-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Cys (SEQ ID NO: 2). The kappa -conotoxin peptides generally have a core sequence termed the kappa 7/2/1/3 core and is represented as Cys-Cys-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Cys-Xaa-Xaa-Cys-Xaa-Cys-Xaa-Xaa-Xaa-Cys (SEQ ID NO: 3).
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申请公布号 |
US5589340(A) |
申请公布日期 |
1996.12.31 |
申请号 |
US19950477383 |
申请日期 |
1995.06.07 |
申请人 |
UNIVERSITY OF UTAH RESEARCH FOUNDATION |
发明人 |
OLIVERA, BALDOMERO M.;CRUZ, LOURDES J.;HILLYARD, DAVID R.;MCINTOSH, J. MICHAEL;SANTOS, AMEURFINO D. |
分类号 |
A61K38/00;A61K39/00;C07K14/435;(IPC1-7):C12Q1/68;C12P19/34;C07H21/04 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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