ADENOVIRUS RECOMBINANTS, LEUR UTILISATION POUR PREPARER DES AAV, LIGNEE CELLULAIRE COMPLEMENTAIRE ET COMPOSITIONS PHARMACEUTIQUES LES CONTENANT

摘要

A recombinant adenovirus in which the expression of a nucleic acid sequence coding for at least one homologous or heterologous gene of viral origin is placed under the control of an inducible promoter, is disclosed. The use of such recombinant adenoviruses for preparing AAVs, and a complementary cell line and preparation method therefor, are also disclosed. Furthermore, pharmaceutical compositions containing such an adenovirus are disclosed.