发明名称 |
COMPLEXONES WITH THE STRUCTURE OF N-2-(AZOL-1(2)-YL)ETHYLIMINODIACETIC ACIDS, SYNTHESIS, ANALYTICAL STUDY AND BIOLOGICAL APPLICATIONS |
摘要 |
Complexones having the structure of N-2-(azol-1(2)-yl)ethyliminodiacetic acids, synthesis, analytical study and biological applications, characterized by their complexing capacity over Ca<2+>, Mg<2+> ions and other bivalent cations, lanthanides and transition metals. In the formula azolN-CH2CH2-N (CH2CO2R)2 (I), azol is pirazol; 3,5-dimethylpirazol; indazol; etc. and R is alkyl or H or Na. The compounds having the general formula (I), are obtained by an alkylation reaction of methyl iminodiacetate with N-bromoethylazols and further hydrolysis in acid or basic medium. The process may be modified by alternative synthetic processes which involve N-aminoethylazols as starting materials or the use of cyclization processes in the preparation of N-susbtituted azol. They can be applied in spectroscopy and nuclear magnetic resonance (NMR) imaging of hydrogen or other nuclei as extrinsic probes of Ca<2+>, Mg<2+> or other metal ions and as contrast agents, in solutions, biological extracts, tissues, entire animals and human beings.
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申请公布号 |
WO9641797(A1) |
申请公布日期 |
1996.12.27 |
申请号 |
WO1996ES00129 |
申请日期 |
1996.06.11 |
申请人 |
UNIVERSIDAD NACIONAL DE EDUCACION A DISTANCIA;CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS;BALLESTEROS GARCIA, PALOMA;LOPEZ LARRUBIA, PILAR;CERDAN GARCIA-ESTELLER, SEBASTIAN |
发明人 |
BALLESTEROS GARCIA, PALOMA;LOPEZ LARRUBIA, PILAR;CERDAN GARCIA-ESTELLER, SEBASTIAN |
分类号 |
C07D231/12;C07D231/56;(IPC1-7):C07D231/12;A61K49/00 |
主分类号 |
C07D231/12 |
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