ANALOGS OF DES-TYR-DINORPHINE AND METHOD OF TREATMENT OF PATIENT WITH TOLERANT STATES

摘要

FIELD: medicine, peptides. SUBSTANCE: new peptides are analogs of dinorphine and show activity that is similar with that of endogenous dinorphine though they are des-Tyr- or des-Tyr-Gly-analogs of endogenous dinorphine. New peptides can be administrated to host exhibiting tolerance to narcotic analgetic to enhance narcotic analgetic action and/or block abstinence symptoms. EFFECT: enhanced effectiveness of method.