DRY POWDER FORMULATIONS OF POLYNUCLEOTIDE COMPLEXES

摘要

Polynucleotide complexes are stabilized by adding a cryoprotectant compound and lyophilizing the resulting formulation, The lyophilized formulations are milled or sieved into a dry powder formulation which may be used to deliver the polynucleotide complex. Delivery of the polynucleotide to a desired cell tissue is accomplished by contacting the tissue with the powder to rehydrate it. In a preferred embodiment, a dry powder formulation is used to induce genetic modification of a patient's lung tissue.