Treatment of allograft rejection with IL-2 receptor-specific cytotoxins

摘要

Methods of inhibiting the rejection and prolonging the survival of an allograft in a mammal are provided. The methods involve administering to the mammal a cytotoxin-conjugated IL-2 receptor-specific substance during a proliferative burst of IL-2 receptor-bearing lymphocytes associated with the allograft whereby the lymphocytes undergoing the proliferative burst are selectively killed.