| 摘要 |
PCT No. PCT/EP94/00529 Sec. 371 Date Nov. 4, 1994 Sec. 102(e) Date Nov. 4, 1994 PCT Filed Feb. 24, 1994 PCT Pub. No. WO94/20504 PCT Pub. Date Sep. 15, 1994The present invention provides cephalosporin sulphones of formula (I) and the pharmaceutically and veterinarily acceptable salts thereof: <IMAGE> (I) wherein n is one or two: A and B are both or each independently hydrogen or an organic radical; R1 represents halogen, A, OA, -S(O)mA wherein m is 0-2, -OC(O)A, -OS(O)2A, -NHC(O)A or -NH-Z wherein Z is a mono, di- or tripeptide and A is as defined above; R2 represents a halogen, A, -S(O)mA, -O-A, -C(O)A, -C(O)OA, -CH2-OA, -CH2S(O)mA, -CH2OC(O)A, -CH2O-Z, -CH2SC(O) A, -CH2-N(A)A, -CH2N+(A)(A')A'', -CH2NH-C(O)A or -CH2NH-Z wherein A and Z are as defined above. The compounds of formula (I) and their salts are elastase inhibitors.
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