发明名称 |
Sulfonyloxy-biphenylcarboxylic ester derivatives which are intermediates |
摘要 |
The present invention provides an industrially advantageous process for preparing a 2-alkyl-3-(biphenyl-4-yl)methyl-3H-imidazo[4,5-b]pyridine derivative represented by the following formula (II) which is a precursor of an antagonist against an angiotensin II receptor useful as an antihypertensive drug, a biphenyl derivative which is a precursor of the substituent of the pyridine derivative, a process for the preparation thereof, and an intermediate useful for the preparation of the biphenyl derivative: <IMAGE> (II) The 2-alkyl-3-(biphenyl-4-yl)methyl-3H-imidazo[4,5-b]pyridine derivative can be prepared in a high yield according to the present invention from a 2-amino-5-halogeno-3-nitropyridine derivative through amidation, N-alkylation and reductive cyclization.
|
申请公布号 |
US5587504(A) |
申请公布日期 |
1996.12.24 |
申请号 |
US19950545484 |
申请日期 |
1995.10.19 |
申请人 |
EISAI CO., LTD.;EISAI CHEMICAL CO., LTD. |
发明人 |
URAWA, YOSHIO;FURUKAWA, KEN;SHIMIZU, TOSHIKAZU;YAMAGISHI, YOJI;TSURUGI, TOMIO;ICHINO, TOMIO |
分类号 |
C07C63/72;C07C65/105;C07C69/732;C07C69/76;C07D213/73;C07D213/75;C07D263/10;C07D263/12;C07D263/14;C07D309/12;C07D413/12;C07D471/04;(IPC1-7):C07C409/32 |
主分类号 |
C07C63/72 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|