| 摘要 |
Targeting and effector molecules are conjugated by covalent attachment of the targeting molecule to the effector molecule by a combination of imine formation and thioalkylation. The conjugates are used in therapeutic or diagnostic applications to target the effector molecule to a desired cell or tissue. The immunoconjugates are particularly useful in the treatment of tumors, where, for example, antibody-doxorubicin conjugates are effective against doxorubicin resistant tumor cells. |
