发明名称 |
TWO-DIMENSIONAL SENSOR USING LAPS FOR MEASURING CELL ACTIVITY |
摘要 |
A two-dimensional sensor is described including a substrate having a Si layer, a SiO2 layer and a Si3N4 layer. On the surface of the Si back side, a thin film is formed by vapor deposition for making an effect electrode. On the surface of the Si3N4 front side, a fence is attached for containing a sample cell, culture medium and a reference electrode. This sensor is placed in an incubator and a bias voltage is applied between the effect and reference electrodes. When a high frequency modulated laser beam irradiates a spot of the back side of the sensor substrate, a signal of AC photocurrent is obtained from the effect electrode. This signal corresponds to a potential alteration due to the cell activity substantially at the spot. The signal is processed in a computer. Therefore, the beam spot size and location, corresponding to the size and the location of the measurement electrode, can be adjusted easily by focusing or moving the laser beam.
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申请公布号 |
CA2179459(A1) |
申请公布日期 |
1996.12.21 |
申请号 |
CA19962179459 |
申请日期 |
1996.06.19 |
申请人 |
MATSUSHITA ELECTRIC INDUSTRIAL CO., LTD. |
发明人 |
SUGIHARA, HIROKAZU;TAKETANI, MAKOTO;KAMEI, AKIHITO;IWASAKI, HIROSHI |
分类号 |
G01R19/00;G01N27/30;G01N27/327;G01N27/416;G01N33/487;(IPC1-7):G01N27/327;C12Q1/02 |
主分类号 |
G01R19/00 |
代理机构 |
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代理人 |
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主权项 |
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