发明名称 |
DIAGNOSIS OR PROGNOSIS OF ALZHEIMERS USING THE PRESENCE OF APOLIPOPROTEIN E TYPE 4 AS AN INDICATOR AND APOLIPOPROTEIN E ISOFORM SPECIFIC ANTIBODIES |
摘要 |
Methods of diagnosing or prognosing Alzheimer's disease in a subject are disclosed. The methods involve directly or indirectly detecting the presence or absence of an apolipoprotein E type 4 (ApoE4) isoform or DNA encoding ApoE4 in the subject. The presence of ApoE4 indicates the subject is afflicted with Alzheimer's disease or at risk of developing Alzheimer's disease. A novel immunochemical assay for detecting the presence or absence of the Apoliprotein E (ApoE) E4 allele in a subject is also disclosed. |
申请公布号 |
NZ257215(A) |
申请公布日期 |
1996.12.20 |
申请号 |
NZ19930257215 |
申请日期 |
1993.09.30 |
申请人 |
DUKE UNIVERSITY |
发明人 |
ROSES, ALLEN DAVID;STRITTMATTER, WARREN JAMES;SALVESEN, GUY SELMER;ENGHILD, JAN;SCHMECHEL, DONALD EVERETT |
分类号 |
G01N33/53;A61K39/395;C07K1/28;C07K14/755;C07K14/775;C07K16/00;C07K16/18;C12N15/09;C12P21/08;C12Q1/68;(IPC1-7):G01N33/50;C07K17/00;C07K14/18 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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