PLASMID FOR DELIVERY OF NUCLEIC ACIDS TO CELLS AND METHODS OF USE

摘要

This invention relates to plasmid constructs useful for nonviral human gene therapy. The plasmid constructs incorporate plasmid elements for achieving high copy number, avoiding plasmid instability and providing a plasmid selection process. These constructs can be used to deliver nucleic acids to cells in vehicles which arecompatible with human therapeutic use.