HUMANIZED ANTIBODIES TO E-SELECTIN

摘要

The present invention provides humanized antibodies that specifically bind E-selectin, wherein the antibodies comprise substantially the complementarity determining regions of a non-human antibody and substantially the framework regions (FRs) of a human antibody, where the FRs can be substituted in one or more amino acid positions. The invention also provides nucleic acid molecules encoding the humanized anti-E-selectin antibodies, vectors comprising the nucleic acid molecules, and cells containing the vectors. The invention further provides pharmaceutical compositions comprising a humanized anti-E-selectin antibody and provides methods of using a humanized anti-E-selectin antibody to detect the presence of E-selectin in a human subject and methods to diagnose a pathology characterized by the involvement of E-selectin in a human subject. In addition, the invention provides methods of reducing or inhibiting E-selectin mediated cell adhesion to an endothelial cell in a subject and methods of treating a human subject having a pathology characterized by the involvement of E-selectin by administering a humanized anti-E-selectin antibody to the subject.