MODIFIED alpha -D-Glcp-(1-2)- alpha -D-Glcp-(1-3)- alpha -D-Glcp-ANALOGUES

摘要

Human immunodeficiency viruses (HIV-1 and HIV-2) are known to be the etiological agents of acquired immunodeficiency syndrome (AIDS). The carbohydrate structures on the virus coat proteins, gp120, are necessary for cell-cell fusion. The oligosaccharides on gp120 are processed by the enzyme glycosidase. The trisaccharide, alpha -D-Glcp-(1-2)- alpha -D-Glcp-(1-3)- alpha -D-GlcpO(CH2)8COOMe and its analogues modified at its terminal glucose residues are recognized by the enzyme and can inhibit glycosylation.