The present invention provides novel cryptophycin compounds having structure (I). The present invention also provides methods for producing novel cryptophycins from the Nostoc sp. of blue-green algae (cyanobacteria). Pharmaceutical compositions comprising novel cryptophycins are also provided by the present invention, as are methods for using novel cryptophycins to inhibit the proliferation of hyperproliferative cells. The present invention further provides methods for using novel cryptophycins to inhibit the proliferation of hyperproliferative cells with drug resistant phenotypes, and to treat pathological conditions, such as neoplasia.
申请公布号
CA2223828(A1)
申请公布日期
1996.12.19
申请号
CA19962223828
申请日期
1996.06.07
申请人
WAYNE STATE UNIVERSITY;UNIVERSITY OF HAWAII
发明人
PATTERSON, GREGORY M.L.;SMITH, CHARLES D.;VALERIOTE, FREDERICK A.;MOORE, RICHARD E.;CORBETT, THOMAS H.;GOLAKOTI, TRIMURTULU;MOOBERRY, SUSAN L.