| 摘要 |
The invention provides a reactive derivative of dialkyl amino compounds, particularly dialkyl amino drugs, for facilitating the conjugation of the drug, directly or through a bifunctional spacer, to a carrier compound such as proteinaceous materials. The derivative has formula (a) wherein D is the drug and n is an integer greater than 1, and preferably equal to 2. The drug derivative carrier conjugate can be used as an immunogen for production of antibodies specific to the drug. Additionally, the conjugate can be coupled to a solid support, such as a polymer particle, for use as a particle reagent in immunoassays specific to the drug. |
