| 摘要 |
<p>The invention is related to rules and guidelines for designing heterocyclic bases which, when incorporated into oligonucleotides permit those oligonucleotides to serve as third strand nucleic acids capable of specific binding to complementary double-stranded nucleic acids of any base-pair sequence without a requirement for a purine rich strand. Exemplary bases are shown in the figure which were designed according to the inventive method.</p> |
