NOVEL DOLASTATIN DERIVATIVES, THEIR PREPARATION AND USE

摘要

Novel dolasstatin derivatives of the formula (I): R1R2N-CHX-CO-A-B-D-E-(F)¿t?K, in which R?1, R2¿, A, B, D, E, F, K, X and t have the meanings stated in the description, and the preparation thereof are described. The novel substances have an antineoplastic effect.