| 摘要 |
The present invention provides novel opioid peptides. Disclosed are opioid peptides having the general structure Ac-Phe-Arg-Trp-Trp-Tyr-Xaa-NH2 (SEQ ID No. 1); Ac-Arg-Trp-Ile-Gly-Trp-Xaa-NH2 (SEQ ID No. 2); Trp-Trp-Pro-Lys/Arg-Hisz-Xaaz-NH2 (SEQ ID No. 222); Tyr-Pro-Phe-Gly-Phe-Xaa-NH2 (SEQ ID No. 5); (D)Ile-(D)Met-(D)Ser-(D)Trp-(D)Trp-Glyn-Xaa-NH2 (SEQ ID No. 6); and (D)Ile (D)Met-(D)Thr-(D)Trp-Gly-Xaa-NH2 (SEQ ID No. 7). Within each genus, Xaa is substituted by a specific amino acid. The invention also relates to an opioid peptide having general structure Tyr-A1-B2-C3-NH2 (SEQ ID No. 8), wherein A is D-Nve or D-Nle, B is Gly, Phe, or Trp, and C is Trp or Nap. Also included within the invention are opioid compounds of the general structure MexHyN-Tyr-Tyr-Phez-Proz-NH2 (SEQ ID No. 221) which are peptides modified by permethylation, perallylation, perethylation, perbenzylation or pernaphthylation and which be further modified by reduction.
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