| 摘要 |
<p>The invention relates to a process for producing polymer-polypeptide conjugates with reduced immunogenicity comprising the steps of: a) generating a polymer halogen formiate; and b) conjugating at least one polymer-halogen formiate to at least one attachment group on the polypeptide (Pep). The invention also relates to a polymer-polypeptide conjugate with reduced immunogenicity, an activated polymer for conjugating polypeptides (Pep), and the use of said process for reducing the immunogenicity of polypeptides used for pharmaceutical and/or industrial applications. Finally it is the object of the invention to provide the use of said polymer-polypeptide conjugate for a number of therapeutic and industrial purposes, such as the use in pharmaceuticals, personal care products and detergent compositions.</p> |
