| 摘要 |
<p>The subject invention provides methods for determining whether an agent is capable of either inhibiting or specifically inhibiting the fusion of a CD4+ cell with an HIV-1 envelope glycoprotein+ cell. The subject invention also provides a method for determining whether an agent is capable of specifically inhibiting the infection of a CD4+ cell with HIV-1. This invention also provides an agent determined by the above-described methods. The subject invention further provides methods for quantitatively determining the ability of an antibody-containing sample to either inhibit or specifically inhibit the fusion of a CD4+ cell with an HIV-1 envelope glycoprotein+ cell. The subject invention further provides a method for determining the stage of an HIV-1 infection in an HIV-1-infected subject. The subject invention further provides a method for determining the efficacy of an anti-HIV-1 vaccination in a vaccinated, non-HIV-1-infected subject. The subject invention further provides kits for determining whether an agent is capable of either inhibiting or specifically inhibiting the fusion of a CD4+ cell with an HIV-1 envelope glycoprotein+ cell. The subject invention further provides a method for determining whether an HIV-1 isolate is syncytium-inducing. Finally, the subject invention provides a method for determining the stage of an HIV-1 infection in an HIV-1-infected subject.</p> |
