CATIONIC LIPID ACID SALT OF 3 BETA [N-(N',N'-DIMETHYLAMINOETHANE)-CARBAMOYL] CHOLESTEROL

摘要

This invention discloses a novel cationic lipid acid salt of 3 beta [N-(N',N'-dimethylaminoethane)-carbamoyl] cholesterol. This invention further discloses a transmembrane compatible body suitablefor transfection of animals and animal cells with nucleotides such as DNA, RNA, and synthetic nucleotides. Such transmembrane compatible bodies arise from hydratable non-liposomal halogenated solvent-free lyophilate comprising 3 beta [N-(N',N'-dimethylaminoethane)-carbamoyl] cholesterol and DOPE. This invention yet further discloses a halogenated solvent-free aqueous solution, suitable for lyophilization into a preliposomal powder, wherein the solution comprises 3 beta [N-(N',N'-dimethylaminoethane)-carbamoyl] cholesterol wherein substantially all 3 beta [N-(N',N'-dimethylaminoethane)-carbamoyl] cholesterol is dissolved.