| 发明名称 |
DI- AND TRI-AMINOGUANIDINES AND THEIR USE TO INHIBIT THE ADVANCED GLYCOSYLATION OF PROTEINS |
| 摘要 |
The present invention relates to compounds, compositions and methods for inhibiting nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises a di- or tri-aminoguanidine of formula (I), capable of inhibiting the formation of advanced glycosylation endproducts of target proteins. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated.
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| 申请公布号 |
WO9640663(A1) |
申请公布日期 |
1996.12.19 |
| 申请号 |
WO1996US09376 |
申请日期 |
1996.06.07 |
| 申请人 |
ALTEON INC.;THE ROCKEFELLER UNIVERSITY |
发明人 |
CERAMI, ANTHONY;WAGLE, DILIP, R.;ULRICH, PETER, C. |
| 分类号 |
A61K8/43;A61K31/15;A61K31/155;A61K31/195;A61K31/415;A61K31/4178;A61K31/4468;A61K31/495;A61K31/535;A61K31/5375;A61K31/55;A61K38/19;A61K38/20;A61K38/21;A61K38/38;A61K39/00;A61Q11/00;A61Q19/08;C07C281/16;C07D233/02;C07D239/04;C07D243/04;C07D295/215;C07D295/28;C07D405/14;C07K16/28;G01N33/533;G01N33/573;G01N33/68;(IPC1-7):C07D295/14;A61K31/445;C07D295/20;C07C279/08 |
主分类号 |
A61K8/43 |
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