发明名称 |
COMPOSITION FOR SUSTAINED RELEASE OF NON-AGGREGATED ERYTHROPOIETIN |
摘要 |
A composition, and methods of forming and using said composition, for the sustained release of non-aggregated, biologically active, erythropoietin (EPO). The sustained release composition of this invention comprises a polymeric matrix of a biocompatible polymer and particles of biologically active, aggregation-stabilized EPO, wherein said particles are dispersed within the biocompatible polymer. The method of the invention for producing a composition for the sustained release of biologically active EPO, includes dissolving a biocompatible polymer in a polymer solvent to form a polymer solution, dispersing particles of biologically active, aggregation-stabilized EPO in the polymer solution, and then solidifying the polymer to form a polymeric matrix containing a dispersion of said EPO particles. The method for using a composition of the invention is a method for providing a therapeutically effective blood level of biologically active, non-aggregated erythropoietin in a subject for a sustained period. In this method, a subject is administered an effective dose of the sustained release composition of the present invention. |
申请公布号 |
WO9640073(A2) |
申请公布日期 |
1996.12.19 |
申请号 |
WO1996US08474 |
申请日期 |
1996.06.03 |
申请人 |
ALKERMES CONTROLLED THERAPEUTICS, INC. |
发明人 |
ZALE, STEPHEN, E.;BURKE, PAUL, A.;BERNSTEIN, HOWARD;BRICKNER, AVRAM |
分类号 |
A61K9/00;A61K9/16;A61K9/50;A61K9/51;A61K9/52;A61K38/17;A61K38/18;A61K38/22;A61K47/02;A61K47/12;A61K47/18;A61K47/26;A61K47/30;A61K47/32;A61K47/34;A61K47/42;A61P7/00 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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