| 摘要 |
<p>The present invention is directed to a method of treating respiratory infections caused by a bacteria selected from the group consisting of S. pneumoniae, H. influenzae, H. parainfluenzae, Burkholderia (Pseudomonas cepacia) and a mixture thereof, by administering a binding inhibiting effective amount of the compound of formula (I), where R1 is H, (β-1)GalNAc-, SO3B (where B is H or a cation) or a sialic acid of formula (II), where R6, R7, R8, and R10 are each independently H, C1-6 acyl, lactyl, C1-6 alkyl, sulfate, phosphate, anhydro, a sialic acid of formula (II), (α-1)Fuc, (β-1)Glc or (β-1)Gal; R9 is NH-C1-6 acyl, glycolylamido, amino or hydroxyl; and A is H or a cation; R2 is H or (α-1)Fuc-; R3 and R4 are each independently OH or NHAc; R5 is H, SO3B (where B is H or a cation) or a sialic acid of formula (II) as defined above; and Y is a chemical bond or a linking group; Z is H or a multivalent support; m is 0 or 1; and p is an integer of 1 to 1,000; and a pharmaceutical composition containing same.</p> |
