发明名称 |
USE OF 4-SUBSTITUTED 2-BUTANONES TO PREPARE NABUMETONE |
摘要 |
The palladium-catalyzed coupling of aryl and vinyl halides with vinylic compounds is disclosed. A preferred embodiment relating to the palladium catalyzed coupling of 4-substituted and 6-substituted-2-methoxynaphthalene to form nabumetone is also disclosed. The beauty of this novel reaction is that methylvinylketone, normally employed by the art directly as-is for the preparation of nabumetone, is formed in situ. We have discovered a mechanism to take advantage of the in situ formation of methylvinylketone, thus avoiding the use of expensive, toxic, and unstable methyl vinyl ketone feed. This reaction may be employed for a variety of pharmaceutically active and non-pharmaceutical compounds. |
申请公布号 |
WO9640608(A2) |
申请公布日期 |
1996.12.19 |
申请号 |
WO1996US06729 |
申请日期 |
1996.05.10 |
申请人 |
HOECHST CELANESE CORPORATION |
发明人 |
FRITCH, JOHN, R.;ASLAM, MOHAMMAD;RIOS, DORA, E.;SMITH, JOEL, C. |
分类号 |
A61K31/12;C07B61/00;C07C45/62;C07C45/68;C07C45/71;C07C49/255 |
主分类号 |
A61K31/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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