| 摘要 |
Transformed B cell lines secrete into a human serum culture medium under controlled conditions an inhibitor of IL-6. The cell culture medium, or purified fractions thereof having IL-6 inhibitory activity, can be administered to treat patients having disorders characterized by elevated levels of IL-6, particularly certain types of cancers, autoimmune disorders, pain associated with these disorders, side effects arising from chemotherapy, and wasting or other symptoms of certain viral diseases. The preferred cell line is RPMI 1788, from the American Type Culture Collection, although other B cell lines can also be used as a source of active material. Examples demonstrate efficacy in treatment of cancer patients and autoimmune disorders.
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