摘要 |
The instant invention is directed to the use of a biologically compatible composition, containing an effective amount of a metal-independent nitroxide compound which is preferably represented by formula (I), wherein R1 is -CH3; R2 is -C2H5, -C3H7, -C4H9, -C5H11, -C6H13, -CH2-CH(CH3)2, -CHCH3C2H5, or -(CH2)7-CH3, or wherein R1 and R2 together form spirocyclopentane, spirocyclohexane, spirocycloheptane, spirocyclooctane, 5-cholestane, or norbornane, R3 is -O. or -OH, or a physiologically acceptable salt thereof, and a pharmaceutically acceptable carrier, as antioxidants capable of protecting cells, tissues, organs, and whole organisms against the deleterious effects of harmful free radical species generated during oxidative stress.
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申请人 |
THE UNITED STATES OF AMERICA, REPRESENTED BY THE S |
发明人 |
MITCHELL, JAMES, B.;SAMUNI, AMRAN;DEGRAFF, WILLIAM, G.;HAHN, STEPHEN |