AMINOSTEROL COMPOUNDS USEFUL AS INHIBITORS OF THE SODIUM/PROTON EXCHANGER (NHE), PHARMACEUTICAL METHODS AND COMPOSITIONS EMPLOYING SUCH INHIBITORS, AND PROCESSES FOR EVALUATING THE NHE-INHIBITORY EFFICACY OF COMPOUNDS

摘要

Aminosterol compounds are described that are useful as inhibitors of the sodium/proton exchanger (NHE). Methods of using such aminosterols compounds are also enclosed, including those employing compounds that are inhibitors of a spectrum of NHEs as well as those using compounds that are inhibitors of only one specific NHE. Advantageous screening techniques and assays for evaluating a compound's therapeutic activity are also disclosed.