MONOSPECIFIC ANTIBODIES AGAINST A SUBUNIT OF FIBRINOGEN

摘要

The invention provides monospecific antibodies which are specifically reactive with the .alpha.E subunit of fibrinogen or a fragment thereof, but not with other portions of the fibrinogen molecule. The invention also provides anti.alpha.E probes, including monospecific anti-.alpha.E antibodies which have been detectably labeled. In addition, the invention provides methods for using the monospecific antibodies for detection of the .alpha.E subunit and fragments thereof, as well as reagents and kits performing the methods. Diagnostic methods for determining information associated with atherogenesis and/or thrombogenesis, as well as for determining information associated with pregnancy status or outcome. The invention further provides continuous cell lines which produce monospecific anti-.alpha.E antibodies.