METHOD FOR OBTAINING RECEPTOR AGONIST ANTIBODIES

摘要

A method is provided for generating antibodies which demonstrate the agonist properties of the naturally occuring ligand of a receptor molecule by using as an immunogen a recombinant immunogen which corresponds to a multimeric form of a receptor. In this immunogen the extracellular domains are in a similar disposition to that expected for receptors having two or more subunits on the surface of the cell.