发明名称 |
SUBSTITUTED THIAZOLO [3,2-ALPHA]AZEPINE DERIVATIVE |
摘要 |
<p>The present invention relates to a substituted thiazoloÄ3,2-aÜazepine derivative having inhibitory activity against angiotensin I converting enzyme and neutral endpeptidase. The above substituted thiazoloÄ3,2-aÜazepine derivative is represented by the following general formula (I): <CHEM> (wherein R1 represents a hydrogen atom or a protecting group of a thiol group; R2 represents a hydrogen atom, a lower alkyl group, an aryl group which may have a substituent, a hetroaryl group which may have a substituent, a lower alkoxyl group or a lower alkylthio group; R3, R4 and R5 may be the same or different from one another and represent each a hydrogen atom, a lower alkyl group, a lower alkoxyl group, a lower alkylthio group or the like, with the proviso that the case wherein all of R3, R4 and R5 are hydrogen atoms are excepted; R6 and R7 may be the same or different from each other and represent each a hydrogen atom or a lower alkyl group; R8 represents a hydrogen atom or a protecting group of a carboxyl group; and m and m are each independently 0 or, 1 or 2).</p> |
申请公布号 |
EP0719779(A4) |
申请公布日期 |
1996.12.18 |
申请号 |
EP19950921127 |
申请日期 |
1995.06.07 |
申请人 |
EISAI CO., LTD. |
发明人 |
OINUMA, HITOSHI;SUDA, SHINJI;YONEDA, NAOKI;KOTAKE, MAKOTO;MIZUNO, MASANORI;MATSUSHIMA, TOMOHIRO;FUKUDA, YOSHIO;SAITO, MAMORU;MATSUOKA, TOSHIYUKI;ADACHI, HIDEYUKI;NAMIKI, MASAYUKI;SUDO, TAKESHI;MIYAKE, KAZUTOSHI;OKITA, MAKOTO |
分类号 |
A61K38/00;C07D513/04;C07K5/078;(IPC1-7):C07D513/04;A61K31/425;C07D211/60;C07D277/06 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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