发明名称 |
Dampening of an immunodominant epitope of an antigen for use in plant, animal and human compositions and immunotherapies |
摘要 |
The present invention provides a composition that can be administered to a mammal to cause immunoprotection in the mammal against a pathogenic organism that has an immunodominant epitope. The composition includes a modified form of the antigen in which the immunodominant epitope is located. In this modified form, the immunodominant epitope is immunodampened by any of a number of techniques. Examples of immunodampening techniques include addition of N-linked glycosylation sites, change of the net charge on the epitope, and substitution with a tolerated sequence. The composition also includes a pharmacologically acceptable carrier.
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申请公布号 |
US5585250(A) |
申请公布日期 |
1996.12.17 |
申请号 |
US19930109934 |
申请日期 |
1993.08.20 |
申请人 |
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH & HUMAN SERVICES |
发明人 |
GARRITY, ROBERT R.;NARA, PETER L.;GOUDSMIT, JAAP |
分类号 |
C12N15/09;A61K39/00;A61K39/21;C07K14/11;C07K14/16;C12N5/10;C12N15/44;C12N15/48;C12P21/02;C12R1/91;C12R1/92;(IPC1-7):A61K39/21;C12P21/06;C12N15/00;C07K1/00 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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