发明名称 |
IMMUNOASSAY METHOD FOR CORTISOL AND REAGENT USED THEREFOR |
摘要 |
Polyclonal or monoclonal antibodies that specifically recognise cortisol (hydrocortisone) in urine are new, provided that:(a) they are produced by immunising an animal with an immunogen comprising cortisol 3-syn-carboxymethyloxime (I) coupled through the COOH gp. to a macro-mol., or(b) their binding affinity for the histamine conjugate of (I) is ≥ 1 (esp. ≥ 1.5) times their binding affinity for the histamine conjugate of cortisol-3-anti-carboxymethyloxime (II). Also claimed are:(a) (I), (II), their histamine conjugates;(b) a conjugate of (I) and a macro-mol., and(c) the monoclonal antibody produced by hybridoma cell line IMMU-473 (CNCM I-1532). |
申请公布号 |
JPH08333398(A) |
申请公布日期 |
1996.12.17 |
申请号 |
JP19960068224 |
申请日期 |
1996.03.25 |
申请人 |
IMIYUNOTEKU;INST NATL SANTE & RECH MED <INSERM> |
发明人 |
NINA RUPIISHIEN;ERIZABEETO MAPUSU;KATERIINU FURUNIE;SHIYURISUTOFU BARANDO;SANDORIINU PORUTEYUEJI;IBUUKUROODO KIYUIRON |
分类号 |
G01N33/53;A61K39/395;C07J41/00;C07K14/76;C07K16/00;C07K16/26;C07K17/02;C12N15/02;C12N15/09;C12P21/08;C12R1/91;G01N33/534;G01N33/74;(IPC1-7):C07K16/26 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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