| 摘要 |
PURPOSE: To obtain a stable ibuprofen suspension liquid preparation from which stimulating and bitter tastes in taking the preparation are removed or reduced owing to suppression of ibuprofen isolation by blending crude drugs to the suspension liquid preparation containing ibuprofen and a caffeine drug. CONSTITUTION: In this ibuprofen suspension liquid preparation, (A) ibuprofen, (B) a caffeine drug and (C) a crude drug (preferably the crude drug such as Glycyrrhizae Radix, Lumbricus, Cinnamomi Cortex, etc., and its extract) are combined. The amount of the ingredient C to be combined is preferably 0.05-0.5wt.% based on the total preparation. 1-60mg/ml of the ingredient A and 0.5-30mg/ml of the ingredient B can be combined. The objective preparation can be prepared by dissolving a preservative and a sweetener in an aqueous solution in which a pH adjusting agent such as a phosphoric acid buffer solution, etc., is dissolved and having 2.5-4pH, adding the ingredient C and properly adding a surfactant and a thickener and uniformly dispersing them, then adding the ingredients A and B and adding, if needed, an antifebrile and analgesic agent, etc., uniformly dispersing all the ingredients, adjusting the total volume to 100wt.% by adding pure water and finally heat treating the dispersion at 60 deg.C for 10-20min. |
