| 摘要 |
The present invention is directed to naphthalene derivatives of the formula ¢I!: <IMG> ¢I! wherein R1 and R2 are the same or different and each represent H, protected or unprotected OH, one of R3 and R4 is protected or unprotected hydroxymethyl, and the other is H, lower alkyl, or protected or unprotected hydroxymethyl, R5 and R6 are the same or different and each represent H, substituted or unsubstituted lower alkyl, substituted or unsubstituted phenyl or protected or unprotected NH2, or both combine together with the adjacent N to form substituted or unsubstituted heterocyclic group, and pharmaceutically acceptable salts thereof. These compounds showing excellent bronchoconstriction inhibitory activity, and hence, are useful in the prophylaxis or treatment of asthma.
|
