发明名称 |
Antigen-specific activation of unprimed cd8+ t cells |
摘要 |
An artificial antigen-presenting system provides methods and compositions for the activation of unprimed CD8+ T cells in vitro to form specific activated CD8+ T cells (cytotoxic T lymphocytes, or CTL). CD8+ T cells are activated by contacting them with macrophages that present a MHC molecule complexed to an immunogenic peptide, acquired by phagocytosis of the peptide on an artificial support and with an assisting molecule. |
申请公布号 |
AU5801896(A) |
申请公布日期 |
1996.12.11 |
申请号 |
AU19960058018 |
申请日期 |
1996.05.22 |
申请人 |
THE SCRIPPS RESEARCH INSTITUTE |
发明人 |
MARLOES L. H. DEBRUIJN;MICHAEL R. JACKSON;PER A PETERSON |
分类号 |
A61K38/00;C07K14/115;C07K14/145;C07K14/725;C07K14/77;C12N5/0783 |
主分类号 |
A61K38/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|