| 摘要 |
PCT No. PCT/FI96/00295 Sec. 371 Date Nov. 21, 1997 Sec. 102(e) Date Nov. 21, 1997 PCT Filed May 23, 1996 PCT Pub. No. WO96/37456 PCT Pub. Date Nov. 28, 1996The invention relates to compounds of formula (I) wherein R1 is an electronegative substituent, preferably nitro, cyano, formyl or carboxy, R2 is -A-R4, wherein A is a branched or straight chain C1-9 alkylene and R4 is carboxy or 5-tetrazolyl; R3 is an electronegative substituent, preferably nitro, cyano, halogen, formyl, carboxy, C1-5 alkyl carbonyl, aryl carbonyl or SO2R6, wherein R6 is a branched or straight chain C1-5 alkyl, aryl alkyl, aryl or NR7R8, wherein R7 and R8 are independently hydrogen, a branched or straight chain C1-5 alkyl or together form a C3-6 ring; or a pharmaceutically acceptable ester or salt thereof. The compounds are peripheral, long acting COMT (catechol-O-methyl transferase) inhibitors and are useful, e.g., in the treatment of Parkinson's disease and hypertension. |
