| 摘要 |
The instant invention relates to a method for the delivery of antitumor drugs to tumor cells by the administration of a tumor-selective antibody- beta -lactamase conjugate that binds to tumor cells, and the additional administration of a novel polymeric cephalosporin prodrug that is converted at the tumor site, in the presence of the antibody- beta -lactamase, to an active cytotoxic drug. According to a preferred embodiment of this invention, the polymeric cephalosporin prodrug contains a polyethylene glycol or a branched polyethylene glycol moiety. The methods, antibody-enzyme conjugate, prodrugs, pharmaceutical compositions, and combinations of this invention provide for enhanced selective killing of tumor cells and are thus useful in the treatment of cancers and other tumors. |
