摘要 |
PURPOSE: To efficiently obtain the subject compound useful as an intermediate for medicines, agricultural chemicals, etc., by subjecting the mixture of the racemate of an asymmetrical carbon-having aliphatic unsaturated alcohol with an organic acid ester to a steric ester interchange reaction in the presence of a lipase originating from an microorganism and subsequently hydrolyzing the obtained ester. CONSTITUTION: A method for producing the optically active aliphatic unsaturated alcohol comprises subjecting the mixture of an organic acid ester (e.g. vinyl butanoate) with the racemate of an aliphatic unsaturated alcohol [e.g. (R,S)- buten-3-ol] having an asymmetric carbon atom in the molecule and represented by formula I (R1 is a 1-20C aliphatic hydrocarbon; R2 is H, a 1-20C aliphatic hydrocarbon) in the presence of a lipase separated from a microorganism (Candida antatica SP) in a water-immiscible organic solvent (e.g. diisopropyl ether) in the absence of water to esterify only one of the optical isomers in the racemate of the alcohol, and subsequently hydrolyzing the ester into the aliphatic unsaturated alcohol (R) isomer of formula II. |