发明名称 |
Use of nitrogen oxide species and adducts to inhibit skeletal muscle contraction |
摘要 |
A method for inhibiting or relaxing skeletal muscle contractions which comprises contacting said skeletal muscle with a skeletal muscle relaxing amount, and a method for the treatment of disease states resulting from or exacerbated by undesirable contractions of skeletal muscle, which comprises administering a skeletal muscle relaxing amount to an individual in need thereof of a compound selected from the group consisting of nitroxyl ion (NO-), nitrosonium ion (NO+), nitric oxide and nitric oxide adducts or providers. This invention also is directed to stimulating the contraction of muscles in a mammal by administering an effective amount of a nitric oxide synthase inhibitor.
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申请公布号 |
US5583101(A) |
申请公布日期 |
1996.12.10 |
申请号 |
US19940276105 |
申请日期 |
1994.07.15 |
申请人 |
HARVARD COLLEGE;DUKE UNIVERSITY |
发明人 |
STAMLER, JONATHAN;KOBZIK, LESTER |
分类号 |
C07D207/16;A61K31/04;A61K31/095;A61K31/13;A61K31/16;A61K31/198;A61K31/40;A61K31/401;A61K31/403;A61K31/426;A61K31/517;A61K31/519;A61K31/5415;A61K31/549;A61K31/675;A61K33/00;A61K38/00;A61K38/05;A61K38/17;A61K38/55;A61K45/00;A61P43/00;(IPC1-7):A61K31/16;A61K31/195;A61K38/02 |
主分类号 |
C07D207/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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